Since the majority of protein-coding genes in vertebrates have intra-genomic homologues, it has been difficult to eliminate the potential of functional redundancy from analyses of mutant phenotypes, whether produced by genetic lesion or transient knockdown.Further complicating these analyses, not all gene products have activities that can be assaye
Gastrointestinal stromal tumors (GISTs) are rare and current estimates range from 4,000 to 6,000 number of GIST cases in the USA annually.Imatinib, a tyrosine kinase inhibitor, has shown a survival benefit in GISTs, and the presence of KIT mutation status is diablo 2 amn predictive of response.The current case discusses rapidly progressive dyspnea
Abstract Endometriosis (EMS) is a prevalent gynecological condition lacking reliable diagnostic biomarkers.This prospective study aimed to analyze the potential of serum heat shock transcription factor 1 (HSF1) as 5.7 procharger a diagnostic marker for EMS.Clinical features of 92 EMS patients and 52 controls were recorded, revealing significant dif
Abstract Recently, radiotherapy (RT) has entered a new realm of precision cancer therapy with the introduction of magnetic resonance (MR) imaging guided radiotherapy systems into the clinic.Nonetheless, identifying an optimized radiotherapy time window (ORTW) is still mintkuler critical for the best therapeutic efficacy of RT.Here we describe pH an
Utilizing ENU mutagenesis, we identified a mutant mouse with elevated platelets.Genetic mapping localized the mutation to an interval on chromosome 19 that encodes the Jak2 tyrosine kinase.We identified a A3056T mutation resulting in a premature stop codon within exon 19 of Jak2 shades 4nch (Jak2(K915X)), resulting in a protein truncation and funct